From Risk Targets to Structural and Dynamic Review
Graphical abstract
Summary
Network toxicology, structural review and dynamics are combined to rank risks while preserving the distinction between signals and toxicological evidence. The graphical abstract connects network, functional and structural results across the evidence layers. The cross-layer results establish focused priorities for targets, pathways and mechanistic investigation. The result-focused presentation supports efficient review of the main evidence and research priorities.
Computational results
Analysis of the binding mode
This figure presents the principal structures and trends in “Analysis of the binding mode” and connects them to the case-level ranking and result interpretation.
This figure presents the principal structures and trends in “Analysis of the binding mode” and connects them to the case-level ranking and result interpretation.
This figure presents the principal structures and trends in “Analysis of the binding mode” and connects them to the case-level ranking and result interpretation.
This figure presents the principal structures and trends in “Analysis of the binding mode” and connects them to the case-level ranking and result interpretation.
Full case PDF
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